Nigeria

Sickle Cell: Why intending couples should know their genotypes

By Maimunna Katuka Aliyu

Understanding blood types and genotypes is crucial for emergencies, such as blood transfusions during accidents. However, knowing one’s genotype, particularly before marriage, is equally important to avoid having children with Sickle Cell Disease (SCD).

Blood genotypes determine an individual’s blood type, inherited from our parents and remain constant throughout our lives. The four main blood types are A, B, AB, and O, classified based on the presence of antigens in red blood cells. The Rh factor can also be present (Rh-positive) or absent (Rh-negative), further defining blood types.

Blood genotypes play significant roles in the following:
– Blood Transfusions: Ensuring compatibility between donor and recipient blood.
– Pregnancy: Preventing complications like haemolytic disease of the newborn.
– Organ Transplants: Matching donor and recipient blood types for successful transplants.
– Disease Susceptibility: Influencing susceptibility to diseases like sickle cell anaemia.

Sickle cell disease is a genetic disorder affecting haemoglobin production, leading to abnormal red blood cells. These cells become crescent-shaped and rigid, causing a range of health problems. The genotype responsible for SCD is known as HbSS or HbSβthal, resulting from a mutation in the HBB gene.

Individuals with sickle cell disease have two copies of the mutated gene (HbSS), while those with one normal gene and one mutated gene (HbAS) have the sickle cell trait but generally remain healthy. Understanding an individual’s genotype is crucial in determining their risk of developing SCD or passing it to their offspring.

The symptoms of sickle cell disease can vary in severity and include:
– Anemia
– Fatigue
– Shortness of breath
– Pale skin
– Yellowing of the skin and eyes (jaundice)
– Painful episodes (crises)
– Swelling of hands and feet
– Increased risk of infections

While there is no cure for sickle cell disease, several management options help alleviate symptoms and prevent complications:
– Pain Management: Medications like acetaminophen and ibuprofen.
– Blood Transfusions: Increasing healthy red blood cell levels.
– Hydroxyurea: Reducing the frequency of painful episodes and improving anaemia.

Aisha Mahmud, a sickle cell patient diagnosed at age three, shared her experiences. As she grew older, the frequency of her crises reduced, occurring only once every three months. She regularly visits Primus Hospital in Karu, Abuja, and FMC Azare for checkups. Aisha emphasises that emotional stress often triggers crises, highlighting the importance of therapy over medication. Remarkably, her genotype changed from SS to AC, bringing immense joy to her family.

The challenges faced by sickle cell patients are immense, impacting them physically, psychologically, emotionally, and financially. Crises can occur unpredictably, causing significant distress to patients and their families.

Researchers are continuously exploring new treatment options for sickle cell disease. Some of the latest developments include:

– Hydroxyurea: Reduces pain crises and acute chest syndrome, decreasing the need for blood transfusions.

– Voxelotor: Approved for people age four and older to reduce pain crises and improve anaemia.

– Crizanlizumab: Approved for people age 16 and older to reduce pain crises.

– L-glutamine: Approved for people age five and older to reduce pain crises.

– Bone Marrow Transplant: Can cure some individuals with SCD but requires careful consideration and a suitable donor.

– Gene Therapy: Genes are used to correct the mutations that cause sickle cell disease.

– CRISPR Technology: A gene-editing tool that corrects the mutation causing SCD.

In conclusion, sickle cell disease is a complex and debilitating genetic disorder affecting millions worldwide. While there is no cure, management options help alleviate symptoms and prevent complications. Ongoing research and new treatment options offer hope for improved treatment and potentially a cure in the future.

Maimunna Katuka Aliyu wrote via munat815@gmail.com.

7.5% VAT rate remains — FG

By Anwar Usman

Mr. Wale Edun, the Minister of Finance and Coordinating Minister of the Economy, has debunked reports suggesting an increase in the Value-Added Tax rate from 7.5 percent to 10 percent.

In a statement signed by him on Monday, Edun clarified that the VAT rate remains unchanged at 7.5 percent, as stipulated in the nation’s tax laws.

Edun reiterated that “the current VAT rate is 7.5%, and this is what the government charges on a spectrum of goods and services to which the tax is applicable. Therefore, neither the Federal Government nor any of its agencies will act contrary to what the laws stipulate.”

He further explained the importance of maintaining a balanced tax system, emphasizing that Nigeria’s tax framework is built on three key pillars: tax policy, tax laws, and tax administration.

While addressing concerns over government actions perceived as anti-human, Edun reassured Nigerians that fiscal policies are designed to promote sustainable economic growth and alleviate poverty, not to hinder them.

The Minister also stated, “Our focus as a government is to use fiscal policy in a manner that promotes and enhances strong and sustainable economic growth, reduces poverty, and makes businesses flourish.”

Fuel price hike pushes Nigerians to breaking point – NLC, Atiku sound alarm

By Uzair Adam

The Nigeria Labour Congress (NLC) and former Vice President Atiku Abubakar have issued warnings that the recent increase in petrol prices by the Federal Government is pushing many Nigerians to a breaking point.

This comes as prominent human rights lawyer Femi Falana, SAN, calls on the government to complete the rehabilitation of the nation’s refineries by September 2024 or take legal action against contractors for failing to meet project deadlines.

The Socio-Economic Rights and Accountability Project (SERAP) also urged President Bola Tinubu to order the Nigerian National Petroleum Company Limited (NNPCL) to reverse the price hike, labeling it as “illegal and unconstitutional.”

While the NLC advocated for public resistance to the fuel price increase, Atiku highlighted that the government’s plans to raise Value Added Tax (VAT) would further worsen the economic strain on citizens.

NLC President Joel Ajaero, represented by Prince Adewale Adeyanju at a Labour Writers Association of Nigeria workshop, decried the combination of fuel price hikes, naira devaluation, and rising electricity tariffs as policies that have deepened the struggles of ordinary Nigerians.

Atiku also voiced concerns that the VAT increase, following the petrol price surge, would severely impact the country’s already fragile economy and the livelihoods of Nigerians, compounding the existing cost-of-living crisis.

SERAP demands immediate reversal of petrol price hike, probe into affairs of NNPC

By Uzair Adam

The Socio-Economic Rights and Accountability Project (SERAP) has urged President Bola Tinubu to take swift action in reversing the recent increase in the price of premium motor spirit (PMS), commonly known as petrol, at Nigerian National Petroleum Company Limited (NNPCL) outlets.

In an open letter dated September 7, 2024, signed by SERAP Deputy Director Kolawole Oluwadare, the organization deemed the price hike unlawful and a violation of constitutional and international human rights obligations.

SERAP also called for a thorough investigation into allegations of corruption and mismanagement within the NNPC, specifically regarding the reported $300 million bailout funds received from the Federal Government in August 2024 and the company’s $6 billion debt to suppliers.

The letter highlighted concerns over NNPC’s failure to remit oil revenues to the treasury, despite the company’s significant financial issues.

The group expressed concerns that the petrol price increase, which has pushed prices up to N855 per liter at some outlets, is exacerbating the already severe economic hardships faced by Nigerians.

SERAP further noted that the price hike disproportionately impacts the most vulnerable citizens, jeopardizing their living conditions and undermining their basic human rights.

SERAP warned that if no action is taken within 48 hours of the receipt of the letter, it will consider taking legal measures to compel the government to address the situation.

What lead did to Zamfara and its people

By Dr. Abdulkadir Lawan

A putatively held belief is that the banditry and crime in the Zamfara region of Nigeria cannot be unconnected to the politics of gold and other natural resources mining. But something deadlier than politics, a stealthy by-product of crude extraction methods at the core of gold mining, might have played a leading role in the increase in crime we are witnessing today in the region. 

In the early 2000s, possibly due to the recent change in rule from a military to a democratic one, a renewed gold interest in Zamfara resulted in a mini gold rush. Women and men in the villages would dig out rock ore and extract the gold through crushing and grinding; the resulting dust was contaminated with lead. Some even brought this newfound work to their homes, contaminating their food, water, clothes, and, most dangerously, children. What followed in child deaths from lead poisoning created an unintended raucous through polio vaccination outreach and ended up inviting several efforts to clean up the areas and treat the surviving children.

It is well known that lead is dangerous, even in small doses. It mimics calcium in the body and can be stored in bones, continuing to poison the body even years after initial exposure. The brain is the most sensitive organ to lead. It basically blocks the release of neurotransmitters, which causes headaches and memory loss, and children are especially susceptible. There is no doubt among scientists that lead exposure can cause permanent learning disorders and behavioural problems.

Studies on baby teeth showed that even lead exposure well below the “safe” level results in delayed learning, decreased IQ and increased behavioural problems. There was a direct correlation between lead in children and the inability to graduate from high school in the US. While the CDC has since lowered the acceptable levels of lead in children’s blood from 60ug/dL to 3.5ug/dL over the years, there is no safe lead level as far as it is known today.

Globally, about 65% of all unexplained intellectual disability are believed to be caused by lead. Many countries have monitored the levels of lead exposure in their children over time. In Nigeria, we have little to no data nationwide. A particular US data, however, shows troubling correlations. 

Violent crimes steadily rose from the 1970s to the 1990s before abruptly declining. The troubling part? A graph of average preschool blood lead levels looked strikingly similar to crime levels roughly twenty years apart. The question was whether kids exposed to higher levels of lead grew up to commit more crimes.

The same pattern appears in Britain, Canada, and Australia. In another study, the lead concentrations in the blood of those arrested for violent and anti-social behaviour could not have been more correlated with their behaviour. This shows that lead is at least very likely responsible for some of the increase in crime. 

Whatever the reason for the resurgence of artisanal gold mining in Zamfara in the early 2000s, children raised in that period were in their early teens and 20s when the country began to witness an upsurge in bandit activities at the start of 2010. Thankfully, considerable clean-up efforts and community sensitisation mean there is an unlikely recurrence of lead poisoning effects on this scale around the region. A decline in violent activities can only then be hoped for. 

Glissading along the same line, the biggest source of lead pollution worldwide was the tetraethyl lead compound that was added to gasoline to make leaded fuel. Nigeria completely phased out leaded gasoline in 2004, as did all other countries between 1986 (Japan) and 2021 (Algeria). Nigeria witnessed a record period of civil violence from the 1970s until about the early 2000s. The current crop of our, in my opinion, clearly cognitive-declined politicians was the most exposed to vehicular lead poisoning in the same generation as the perpetrators of multiple violent religious and ethnic crises.

The dangers of lead had already been known for hundreds of years. In 1786, Benjamin Franklin remarked that lead had been used for far too long considering its known toxicity – “This, my dear friend, is all I can at present recollect on the subject. You will see by it that the opinion of this mischievous effect from lead is at least above sixty years old. And you will observe with concern how long a useful truth may be known and exist before it is generally received and practised on.” 

Scientists decided to add lead to fuel one hundred and fifty years later (i.e., after Benjamin Franklin’s speech). Almost one hundred years after that, the juveniles among our (Nigerian) citizenry were exposed to lead, leaving a nation to wonder why there is so much crime in our time.

Dr. Abdulkadir Lawan wrote via abdullwn@gmail.com.

Kano state postpones school resumption date, cites urgent reasons

By Uzair Adam

The Kano State Government has delayed the resumption of both primary and secondary schools for the 2024/2025 academic session, initially set for September 8th and 9th.

The postponement was confirmed in a statement by the Director of Public Enlightenment at the Ministry of Education, Balarabe Abdullahi Kiru, on Saturday.

According to the statement, the Commissioner of Education, Alhaji Umar Haruna Doguwa, cited urgent reasons for the decision, emphasizing that it was made to improve the learning environment for students.

Doguwa said, “I wish to inform pupils, students, and parents that the previously announced resumption dates are now postponed.

“This decision will help create a more conducive learning atmosphere for our children.

“A new resumption date will be communicated in due course,” the statement read.

The ministry urged students and parents to bear with any inconvenience caused by the delay, assuring them that it was in the best interest of improving educational conditions in the state.

Classroom Dynamics: A call for modern teaching methodologies in Nigeria

By Buba Kamal Danladi

In education, the approach to teaching is as crucial as the content itself. Teaching methodology, the comprehensive plan or strategy for systematically presenting material in the classroom, goes beyond merely delivering facts. It embodies beliefs about learning and teaching and specific techniques and activities aligned with these ideologies.

The choice of teaching methodology profoundly influences knowledge acquisition, skill development, and capacity building. Educators must embrace innovative methods that promote critical thinking and interactive learning in an era that transcends traditional role learning. This is especially pivotal in Nigerian tertiary institutions, where outdated teaching approaches often lead to disengagement and subpar academic performance.

Several methodologies warrant attention and adoption in Nigerian educational settings, such as Differentiated Instruction, Catering to diverse learning styles and abilities; Lecture-Based Learning, Traditional yet evolving to include interactive elements; Inquiry-Based Learning, Encouraging curiosity and critical analysis; Technology-Based Learning, Integrating digital tools to enhance understanding; and kinesthetic Learning: Emphasizing hands-on experiences and physical engagement. 

Reflecting on my undergraduate experience at Skyline University Nigeria, I recall the transformative impact of Mr. Abdulhameed Olaitan Ridwanullah’s teaching methods. He epitomised effective education through interactive sessions that valued each student’s thoughts and promoted a culture of inquiry and confidence. His teaching philosophy centres on interactive and student-centred learning. 

Unlike the conventional lecture-heavy approach, his classes are characterised by lively discussions, group projects, and the use of technology to facilitate learning. By integrating digital tools into his curriculum, he engages students and equips them with essential skills for the modern workforce. This tech-savvy approach is particularly relevant in mass communication, where understanding digital platforms is crucial.

Also, his departmental seminar, which he organised, nurtured my public speaking ability. He mandated that all students offering his courses research specific topics and present their findings to seasoned academics. Many students at first despised it, but as some of us inevitably embraced it, it became a ritual. 

The students’ seminar approach not only fostered a deep understanding of the themes the students researched but also ignited a passion for learning, a stark contrast to the disinterest prevalent in many Nigerian institutions.

Educators must critically assess and adapt their teaching strategies to address the disconnect between teaching methodologies and student engagement. The goal is to cultivate an environment where learning is not a passive experience but a vibrant journey of discovery.

However, the transition to such innovative teaching practices requires systemic changes. It calls for investment in digital infrastructure, teacher training, and curriculum development. Policymakers and educational institutions must recognise the value of these modern methodologies and provide the necessary support and resources to implement them.

To our students, I offer this reminder: “Do not merely pass through school; let the transformative power of education pass through you.” Embrace learning as an active participant, for the quality of your education shapes your future.

Buba Kamal Danladi writes from Lagos via kamalbuba05@gmail.com.

NNPCL refutes MURIC’s claims on Petrol pricing, Dangote refinery

By Uzair Adam

The Nigerian National Petroleum Company Limited (NNPCL) has disputed claims made by the Muslim Rights Concern (MURIC) regarding the pricing of Premium Motor Spirit (PMS) and its impact on the Dangote Refinery.

MURIC had asserted that recent adjustments to petrol prices would prevent the Dangote Refinery from offering lower prices and that NNPCL had become the exclusive offtaker of all products from the refinery.

In a statement released by NNPCL’s Chief Corporate Communications Officer, Olufemi Soneye, the company clarified that petroleum product pricing, including that from the Dangote Refinery, is dictated by global market forces.

The recent changes in PMS pricing, it noted, do not affect the refinery’s access to the Nigerian market.

NNPCL noted that the refinery could sell its products at lower prices if the current market rates are perceived as high, and reiterated that domestic refining does not guarantee lower prices when compared to global parity pricing.

Furthermore, NNPCL stated that it would only become a full offtaker from the Dangote Refinery if PMS market prices exceeded local pump prices.

It also made clear that both the Dangote Refinery and other domestic refineries are free to sell directly to any marketers on a willing buyer, willing seller basis.

NNPCL denied any intention of becoming the sole distributor for the refinery’s products and underscored its billion-dollar investment in the business, urging MURIC to verify facts before making public statements that could incite the public.

Edo state postpones school resumption due to fuel price hike

By Uzair Adam

The Edo State Government has indefinitely postponed the resumption of all schools in the state in response to the recent hike in fuel prices.

This decision was conveyed through a memo from Ojo Akin-Longe, the Permanent Secretary of the Ministry of Education, in Benin on Saturday.

According to the memo, schools, which were set to reopen on Monday, September 9, 2024, will remain closed until further notice.

“The Edo State Government announces the postponement of the resumption of all public and private schools, originally scheduled for September 9, 2024, until further notice,” stated Akin-Longe.

The statement explained that the rising tension stemming from the increase in fuel prices and the financial strain on parents and guardians prompted the government’s decision.

In light of this, the government urged parents and caregivers to closely monitor their children during this period of uncertainty.

Learning under Professor Atta

By Bilyamin Abdulmumin, PhD

You will find some highly versatile members whose contributions drive their areas in every place. The Department of Chemical Engineering at ABU Zaria is no exception. I cannot imagine the department without Professor Atta’s services.

 Advanced Chemical Reaction Engineering is among the PhD courses that ring the bell in the department, thanks to the delivery methods perfected by Prof.

Prof. designed his class with weekly assignments submitted before each session. Students take turns submitting and answering immediate follow-up questions, ensuring that even those copied must read. Adhering to this weekly activity is a Prof trademark except for unusual circumstances, keeping students engaged throughout the week. The more time one dedicates to a topic, the better one understands it.

There is also a group project where the class is divided into teams. Each team is assigned a research topic to develop into a term paper. This project often includes laboratory work, computational work, or both to publish a paper in a respected journal. Like the weekly assignments, group work is reported biweekly. The group leader makes a presentation, but each member contributes. Though it is challenging for a group of two or three to produce a paper during coursework, the skill that comes with that is priceless.

Then there is the industrial visit. Prof. Atta ensures that students make at least one visit to a process industry, particularly the Kaduna Refinery and Petrochemical Company (KRPC), to study chemical reaction units such as Fluid Catalytic Cracking (FCCU) and fixed bed reactors. These academic excursions are vital for complementing student knowledge or, as Prof. puts it, making knowledge functional.

During our visit to the KRPC FCC unit, the chief operator unleashed the practical working principles of the process. At the same time, Prof. Atta facilitated the connection between theory and practice to us. The duo of Prof. and the experienced chief technician, a reservoir of experience, kept us on our toes until we wished to call it a day. A colleague turned to me and whispered, “Whenever a chemical reaction is being discussed, Dr. (then) can never have enough.”

Of course, this rigorous teaching approach doesn’t sit well with every student, but that never makes Prof. Atta take his foot off the gas. I was surprised at the end of the coursework when a colleague, who was in collusion terms with the course, declared, “I now understand modelling and simulation for the first time.” This is another reason one should not be deterred by complaints of those he is supposed to train. Trainees often want to avoid the process and jump to the achievement, so a trainer must stick with his gun; as they say, the end justifies the means.

A conducive environment is a major concern for research students in Nigeria. Simple tools like a weighing balance, pH meter, or glassware can affect and slow down research. To address these small but impactful issues, Prof. prepared a mini lab equipped with all basic and some analytical equipment. This lab includes a working area, a reading area, and lockers for everyone.

One day, an MSc student met me in the lab and, after his observations, declared, “You, Prof. students, are enjoying,” as if he would say I will join you. Still, to my chagrin, he confessed: I couldn’t join Prof. because I wasn’t serious enough to qualify to work with him.

Another major concern for postgraduate students is time. Many suffer from a lack of contact time and engagement with their supervisors. However, with Prof. Atta, the story is different. His office is a Mecca for PG students, with students queuing from morning to evening, each waiting for their turn.

 Of course, other significant issues that concern the nation and society pop up and are discussed. As a melting pot, the professor’s office allows free fall for ideas, but primordial affiliation has no place. Such gatherings of students, sometimes Professor colleagues, and visitors from various backgrounds are a rare opportunity not only to get a glimpse into diverse area research and technological trends but also to learn about others’ personal life journeys and ambitions. 

The professor’s dedication to academics is exemplary and worthy of emulation by young (and not-so-young) scholars. It will go a long way to facelift postgraduate study in Nigeria.

Bilyamin Abdulmumin, PhD, wrote via bilal4riid13@gmail.com.