By Mujahid Nasir Hussain
Every human brain tells a story: of love, memory, and motion. Yet, for many Nigerians, these stories are being erased silently by diseases that steal what it means to be human. Alzheimer’s disease, Amyotrophic lateral sclerosis (ALS), Parkinson’s disease, and other neurodegenerative disorders are creeping into our society, affecting not only the elderly but, increasingly, middle-aged adults as well. Their signs often begin subtly: a forgotten name, a misplaced key, and a trembling hand, until the symptoms grow into something that shatters families and identities alike.
I am writing this piece after World Mental Health Day (October 10) to raise awareness about these devastating but often misunderstood brain disorders, and to emphasise why Nigeria must invest in research that explores the molecular roots of neurodegeneration. Behind every fading memory is a biological story waiting to be told; one that may hold the key to prevention, treatment, and hope.
Globally, neurodegenerative diseases are among the fastest-growing causes of disability and death. According to the World Health Organisation, over 55 million people currently live with dementia, and nearly 10 million new cases are recorded each year. Alzheimer’s disease accounts for about 60–70% of these cases. The burden is not only medical but also social and economic, as families face the heartache of caring for loved ones who may no longer recognise them.
In Africa, the crisis is quietly intensifying. A report by Alzheimer’s disease International estimates that by 2050, over 12 million Africans could be living with dementia, a staggering increase that health systems are unprepared for. In Nigeria, accurate statistics are scarce, but hospital reports and community surveys show a growing number of undiagnosed neurodegenerative cases among the elderly. Unfortunately, in many communities, symptoms of neurodegeneration are still seen through the lens of superstition. Some families attribute forgetfulness to witchcraft or punishment from the gods. As a result, patients are hidden away, untreated, and stigmatised, even when medical help could improve their quality of life.
But beyond the surface symptoms lies a world of molecular complexity. In every neuron, RNA and proteins work together in precise harmony, regulating gene expression and cell responses to stress. These molecules form small, dynamic structures known as RNA–protein assemblies that constantly change shape and function in response to the brain’s needs. When this spatio-temporal regulation is disrupted, the way these structures behave across time and space is disrupted, it can cause proteins to misfold and clump together. These toxic clumps interfere with brain cell function, triggering the gradual degeneration that characterises diseases like Alzheimer’s and Parkinson’s. Think of it like a city whose garbage collectors suddenly go on strike. Waste piles up, streets become impassable, and normal life grinds to a halt. That’s what happens inside the brain when these molecular systems fail. The result is memory loss, confusion, speech problems, tremors, and ultimately, the loss of independence.
Sadly, this understanding of disease mechanisms has not yet translated into practical awareness or local solutions in Nigeria. Our health sector remains focused on infectious diseases like malaria, tuberculosis, and HIV, which are undeniably urgent but overshadow chronic illnesses that also deserve attention. Neurodegenerative conditions receive very little research funding, and only a handful of Nigerian universities have well-equipped neuroscience or molecular biology laboratories. This lack of infrastructure makes it difficult for scientists to explore how environmental, nutritional, and genetic factors specific to African populations contribute to neurodegeneration.
We cannot afford to ignore this any longer. With Nigeria’s population ageing rapidly, the number of people at risk of dementia will rise sharply in the next decade. Families and caregivers already face immense emotional and financial strain. A 2023 study published in Frontiers in Public Health noted that dementia caregiving in Africa often leads to burnout, poverty, and social isolation, especially among women who bear most of the burden. This is more than a medical issue; it is a public health and human rights concern.
Raising awareness is the first step. Nigerians need to understand that persistent memory loss, tremors, or difficulty performing everyday tasks are not normal parts of ageing. They may signal conditions that require medical attention. Community health workers should be trained to identify these early signs, and hospitals should include basic neurological screening as part of routine check-ups for older adults.
The second step is research. As a physiologist, I believe that Nigeria’s greatest untapped potential lies in our young scientists and natural resources. There is growing evidence that certain plant-derived compounds, including those found in Habbatus Sauda (black seed) and other indigenous herbs, have neuroprotective properties. Exploring how these natural products influence RNA–protein interactions could open pathways to affordable treatments tailored to our local context. If supported, Nigerian research could not only advance understanding but also drive innovation in neurodegenerative disease therapy.
Finally, there is the matter of policy. The Nigerian government and health agencies must recognise brain health as a national priority. We need a National Brain Health Initiative, one that funds research, trains neurologists, supports caregivers, and integrates neuroscience into medical education. Just as we have campaigns for malaria and maternal health, we should have campaign awareness for dementia, Parkinson’s, and other neurodegenerative diseases. Without deliberate action, the human and economic costs will be overwhelming in the coming decades.
Our brains define who we are. To lose them is to lose ourselves, and yet millions are slipping away unnoticed. This World Mental Health Day, let us broaden the conversation beyond depression and anxiety to include the silent epidemic of neurodegenerative diseases. Let us replace stigma with understanding, neglect with action, and fear with hope. Nigeria must awaken to this reality — that the future of our nation depends not only on the health of our hearts and bodies but also on the preservation of our minds.
Mujahid Nasir Hussain is a physiologist and an explorative researcher in biomedical sciences with a particular focus on Molecular mechanisms underlying neurodegenerative disorders.
